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In vivo:
ILŠ\17A is actively expressed in some intraepithelial lymphocytes (IELs) of small intestine. Isolated small intestine IELs were stained directly without stimulations. Fig 1 shows the GFP expression in IELs of ILŠ\17AŠ\GFP mice.
TGFbeta and ILŠ\6 effects on GFP expression: Sorted na.ve CD4+ T cells were stimulated with plate bound antiŠ\CD3/antiŠ\CD28 in the absence or presence of TGFb (1ng/ml) and ILŠ\6 (20ng/ml). GFP expression was
analyzed after 48 hours of stimulation (Figure 2) .
Our company designs and develops novel and extremely sensitive cytokine reporter mice used for high-through-put screening (HTS) of small pharmaceutical compounds for autoimmune disease treatments.
Our company also supports worldwide life science research by providing carefully designed gene targeting mouse models. Biocytogen provides ultra-clean Specific Pathogen Free (SPF) mice to non-profit academic research entities and for-profit pharmaceutical entities, eliminating the need for quarantine and re-derivation. Instead of using 129 genetic background ES cells, all mouse models generated are in C57BL/6 genetic background, which saves years-of-time compared to backcross breeding. Utilizing our mouse models will save both time and money.