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1.     Senior Scientist I/II, Gene Editing and Gene Targeting

 

Location: Biocytogen Boston - Wakefield, MA    Phone: 781-587-3555 

If interested, please send CV to invivo@biocytogen.com 


Position Summary 

We are seeking a talented molecular and cell biologist to lead on project design for our gene editing/targeting efforts. The candidate will support our genetically modified rodent and cell production team, and will correspond with our clients in industry and academia (USA) ,from project design to product delivery. The candidate should possess an innovative mindset, great attention to detail, and the ability to work collaboratively and with cross-disciplinary teams. 


Responsibilities 

    ● Design and implement CRISPR/Cas9-based gene editing and ES cell homologous recombination-based gene targeting strategies for genetically modified rodent and cell production 

    ● Assess off-target risk of gene editing in mice, particularly structural variants including chromosomal rearrangements and mutations in engineered mice 

    ● Design and troubleshoot experiments, both independently and in collaboration with colleagues and cross-functional groups, to reach desired goals 

    ● Communicate project updates with internal and external partners; listening and paying keen attention to clients 

    ● Participate in the design, development and implementation of new cutting-edge gene editing technology development 

    ● Develop cell-based assays for the optimization and validation of gene editing tools 

    ● Effectively collaborate with a fully integrated team to facilitate the success of projects 

 

Minimum Qualifications 

    ● Ph.D. degree with 3+ years of relevant experience in cell & molecular biology or molecular genetics 

    ● Ability to work independently and successfully in a matrix environment, prioritize and manage multiple tasks simultaneously by balancing competing priorities effectively 

    ● Knowledge of molecular and cellular biology techniques (qPCR, ddPCR, NGS library prep, Western blotting, RNAi, mammalian cell culture, etc.) 

    ● Communication and Teamwork – The ability to work collaboratively with others; the genuine desire to be a part of a team and contribute to team and corporate goals. The ability to effectively express ideas in written and oral context with honesty and transparency 

    ● Able to learn new concepts and new technologies quickly and design gene editing and gene targeting constructs for multi-disciplinary projects 

 

Preferred Qualifications 

    ● Experience with sgRNA design and/or Cas9 modifications for genetically modified rodent models or cell lines 

    ● Knowledge of gene editing with CRISPR/Cas9, including targeting multiple genomic loci 

    ● Ability to make decisions/recommendations for high level strategy and tactical implementation of research efforts 

    ● A high degree of energy, accuracy and attention to detail, and a passion for creating rodent models for drug target identification and validation and drug discovery 

    ● Experience working in fast-paced team environments with stringent project timeline 

    ● Experience with mouse model phenotype analysis and characterization is a big plus 



2.     Senior Immunologist, Antibody in vivo efficacy/toxicity    


Location: Biocytogen Boston - Wakefield, MA    Phone: 781-587-3555 

If interested, please send CV to invivo@biocytogen.com 


Position Summary 

We are seeking a talented molecular immunologist to lead on project design for in vivo efficacy studies which employ immune-oncology antibodies and humanized mouse models. The candidate will perform safety evaluations on these models and will support our clients in industry and academia within USA. The candidate will also lead on designing immune cell and cytokine profiling for antibody in vivo efficacy evaluation. An innovative mindset, attention to detail, listening to clients, and the ability to work collaboratively and with cross-disciplinary teams are ideal characteristics that the candidate should possess. 

  

Major Responsibilities 

    ● Design antibody/immune modulator candidate in vivo efficacy/toxicity studies using genetically modified knockin mouse models ● Lead the project communication with clients on project initiation, preliminary design, data analysis and collection 

    ● Design in vivo efficacy end point data collection and analysis using FACS and ELISA assays, especially lymphocyte and cytokine profiling in mouse serum and tumor tissues 

    ● Define PK, PK/PD, biopharmaceutical modeling & simulation requirements for (nonclinical and clinical) drug development projects and appropriate strategies for global registration

    ● Analyze, interpret and present pharmacology, PK, PK/PD and M&S data generated from internal project teams and provide guidance on project design and execution 

    ● Provide the complete project reports and summaries, which meet regulatory requirements, within agreed timeframes 

    ● Proactively communicate with other function teams to ensure that pre-clinical and clinical pharmacology, PK/PD information is interpreted correctly 

    ● Directly or indirectly take the lead on appropriate pharmacokinetic and biopharmaceutical studies 


Qualifications 

    ● Ph.D. with immunology or immune oncology background 

    ● Experience on lymphocyte isolation, culture, and sorting, profiling, and cytokine profiling analysis from mouse serum or tumor tissues 

    ● Excellent communication and management skills 

    ● Experience in drug discovery and development or a relevant experience, e.g. clinical pharmacokinetics or xenograft mouse models is a plus 

    ● Proven knowledge of PK and PK/PD evaluation techniques, experience working in project teams and knowledge of regulatory requirements 

    ● Experience with cell culture and in vitro assay development is essential 

    ● Experience with experimental SOP in preclinical or clinical study is a plus 

    ● Prior experience of therapeutic antibody drug development or genetically modified mouse models is a big plus 

    ● Individual and team player with passion on drug discovery & development and innovation animal model development   



3.     PK/PD Scientists 

 

Location: Biocytogen Boston - Wakefield, MA    Phone: 781-587-3555 

If interested, please send CV to invivo@biocytogen.com 


Major Responsibilities 

    ● Design and perform preclinical studies with ability to troubleshoot and to guide junior associates 

    ● Carry out antibody/immune modulator candidate in vivo efficacy/toxicity studies using genetically modified mouse models 

    ● Define PK, PK/PD, biopharmaceutical and modeling & simulation requirements for (nonclinical and clinical) drug development projects 

    ● Support projects directed to design and perform preclinical studies 

    ● Analyze, interpret and present PK, PK/PD and M&S data

    ● Prepare summary data for internal discussion and reports to higher level administrator(s) 

  

Qualifications 

    ● Ph.D./MD/Pharm.D. with biological/pharmacology background 

    ● Strong communication and management skills 

    ● 2-3 years of experience with drug discovery and development in biotech, pharmaceutical companies or academic laboratories 

    ● Proven knowledge of in vivo efficacy/toxicity, PK and PK/PD evaluation techniques 

    ● Experience with cell culture and in vitro assay development is helpful 

    ● Experience with cancer xenograft mouse models 

    ● Prior experience with therapeutic antibody drug development or genetically modified mouse models is a plus 

    ● Ability to work independently and on a team, with a passion for drug discovery and innovative animal model development 



4.     PK/PD Research Associates 

 

Location: Biocytogen Boston - Wakefield, MA    Phone: 781-587-3555 

If interested, please send CV to invivo@biocytogen.com 


Major Responsibilities 

    ● Perform preclinical pharmacology studies with troubleshooting capability 

    ● Understand in vivo efficacy/toxicity studies and PK/PD data 

    ● Prepare experimental results summaries and reports to higher level administrator(s) 

    ● Follow and understand SOP procedures and experimental protocols 

    ● Experience working with mouse models 


Qualifications 

    ● Bachelors or Masters degree with biological, pharmacology training or related fields 

    ● Good communication and people skills 

    ● 1-2 years of experience with drug discovery and development in biotech companies or academic research 

    ● Experience with cell culture and in vitro assay development is a plus 

    ● Mouse model experience is a big plus 

    ● Good team player with a passion for scientific research 



5.     Marketing Associate


Location: Biocytogen Boston - Wakefield, MA    Phone: 781-587-3555 

If interested, please send CV/resume to info@biocytogen.com or james.jin@biocytogen.com 


Position Summary

Ambitious, entrepreneurial Marketing Associate needed to help drive the business forward. As as one of Marketing/Sales/Business development team, you will report directly to the Marketing Manager. Must be able to multi-task and work well under deadline pressure.


Major Responsibilities 

    ● Communicate gene targeting principles and services to potential customers clearly and effectively

    ● Conduct marketing surveys; manage customer databases

    ● Develop marketing strategies; manage marketing platforms

    ● Attend trade shows and scientific conferences; visit potential customers on site

    ● Create and prepare marketing materials via graphic design

    ● Project management and live animal shipment

    ● Miscellaneous and temporary tasks


Qualifications 

    ● Bachelor, Master’s or PhD in the Biological Sciences, Public Relations, Marketing, Business and/or related fields

    ● Strong motivation to learn biotechnological knowledge and Marketing/Sales/Business Development

    ● Strong written and oral communication skills in English

    ● Solid English-Chinese translation skills preferred 

    ● Willingness to travel (including lab visiting and trade shows)

    ● Desire and ability to work in a culturally diverse environment

    ● Knowledge on media design is a plus







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