Extreme Genome Editing (EGE) System
Based on CRISPR/Cas9, our innovative EGE system significantly increases homologous recombination (HR) efficiency, saving time on screening founder mice. EGE is compatible with large DNA fragment insertions in mice, rats, and cell lines.
Southern blot analysis, an integral part of the EGE workflow, is used to rule out random genomic insertions.
The AAALAC accredited Haimen Animal Center is capable to raise 3,000,000 Specific Pathogen Free (SPF) animals, continuously providing animal models including highly immune-deficient B-NDG® mouse models and humanized immune checkpoint mouse models.
Taking advantage of a wealth of experience in animal model development, Biocytogen has independently generated and validated a series of immune checkpoint humanized mice. We have the most comprehensive single and double humanized immune checkpoint mouse models in-stock, including B-hPD-1, B-hPD-L1, B-hOX40, B-h4-1BB, and B-hCTLA4.
Using our humanized mouse models, we are able to carry out preclinical in vivo studies. These include pharmacodynamics/pharmacokinetics (PK/PD), toxicity, biomarkers and other research experiments, providing reliable data support for clinical trials of tumor antibody drugs. Several products have entered the Chemistry and Manufacturing Controls (CMC) stage and will be starting clinical trials in both China and the U.S.