Gene Targeting Strategy
The Ins1 gene encodes insulin, which is a hormone produced by beta cells in the pancreas and regulates the metabolism of carbohydrates and lipids. In this strain, CreERT2 recombinase expression is under the control of Ins1 promoter. When crossed with a strain containing a loxP site-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination results in deletion of the flanked sequence in Ins1 expressing cells.
Mice hemizygous for Ins1iCreERT2 gene are viable and fertile without any physical abnormalities.
(B-EM-005) B-Ins1-iCreERT2 mice 【Return list】