Brief introduction: Apoprotein E (ApoE) is a polymorphic protein, playing an important role in transfer, storage, utilization and excretion of lipid. It is an important ingredient of chylomicron (CM), very low density lipoprotein (VLDL), and high density lipoprotein (HDL), and is beneficial for structural stability of these lipoproteins (LP); ApoE is also closely associated with hyperlipidemia, atherosclerosis (AS), and CHD.
B-ApoE KO mice are mouse models with a homozygous deletion in the third exon of ApoE, which is prepared using homologous recombination. This mouse model shows symptoms of abnormal hyperlipidemia, and has artery fat accumulation at the age of three months. As age increases, a great deal of damage similar to early stage atherosclerosis occurs. Lipomatous fibromas occur in brains of 17 months old mice. The latest study shows that the gene knockout mice have learning and memory disorders. ApoE gene is a hot point of study in China and overseas, and is associated with diseases such as CHD, hyperlipemia, cerebral infarction, AD, and chronic hepatitis B. B-ApoE KO mice are important models for studying the gene and its multiple related diseases.
Phenotypic characteristics: B-ApoE KO mice show symptoms of abnormal hyperlipemia, and have a great deal of damage like early stage atherosclerosis as month age increases.
ApoE is related to diseases such as coronary heart disease (CHD), hyperlipemia, cerebral infarction, alzheimer disease (AD), and chronic hepatitis B.