Biocytogen

Animal Models and Cell Lines

>Double Humanized Immune-Checkpoint Mice

B-hPD-1/hBTLA mice


Basic characteristics

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Targeting strategy


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Protein Expression Analysis

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Fig 1. Splenocytes from both wild type (WT) C57BL/6 and homozygous B-hPD-1/hBTLA mice were analyzed by flow cytometry. Mouse PD-1+ T cells were detectable in the WT C57BL/6 mice, while human PD-1+ T cells were detectable in the homozygous B-hPD-1/hBTLA mice.


 

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Fig 2. Splenocytes from both wild type (WT) C57BL/6 and homozygous B-hPD-1/hBTLA mice were analyzed by flow cytometry. Mouse BTLA+ B cells were detectable in the WT C57BL/6 mice, while human BTLA+ B cells were detectable in the homozygous B-hPD-1/hBTLA mice.


 

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