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>The Mouse Model and Efficacy Evaluation of Immunological Checkpoint

Gene description

CD27 is a TNF receptor super family member. It is expressed on the surface of T and B cells, and its  binding with CD70 provides a co-stimulatory signal for T and B cell proliferation and for B cells producing immunoglobulins. Treating mice with a CD27 agonist antibody effectively enhanced the antitumor immune response for lymphoma and B16  melanoma, providing putative targets for tumor immunotherapy.


Human CD27 mAb efficacy evaluation (MC38 cell line)

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Fig 1. Murinecolon cancer MC38 cells were subcutaneously implanted into heterozygous B-hCD27 mice. Mice were divided into control and treatment groups (n=5) when the tumor size was approximately 100 mm3. Anti-hCD27 antibody significantly inhibited tumor growth in heterozygous B-hCD27 mice, suggesting that the B-hCD27 mouse model is an effective tool for in vivo hCD27 antibody efficacy studies. (A) Tumor average volume ± SEM, (B) Mice average weight ± SEM.


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