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>The Mouse Model and Efficacy Evaluation of Immunological Checkpoint

Gene description

TIM3 (T-cell immunoglobulin domain and mucindomain-3) is an activation-induced inhibitory molecule involved in immune tolerance and T-cell exhaustion in chronic viral infection and cancers. TIM3 maturation and cell surface expression is facilitated by forming a heterodimeric interaction with CD66a. Co-blockade of CD66a and TIM3 enhanced anti-tumor immune responses, and eliminated tumors in mouse colorectal cancer models.

Human TIM3 mAb efficacy evaluation (MC38 cell line)


Fig 1. Murine colon cancer MC38 cells were subcutaneously implanted into homozygous B-hTIM3 mice. Mice were divided into control and treatment groups (n = 5) when the tumor volume was about 100 mm3. The anti-human TIM3 antibody significantly inhibited tumor growth in homozygous B-hTIM3 mice, suggesting that the B-hTIM3 mouse model is an effective tool for in vivo hTIM3 antibody efficacy studies. (A) Tumor average volume ± SEM, (B) Mice average weight ± SEM.

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