Fig 1. Different treatments show varying efficacies on the same gastric sample in the PDX model.
Preclinical animal test samples can be collected from PDX models that are given different drug combinations to determine appropriate clinical therapies.
Fig 2. Different treatments show varying efficacies on the same lung-tumor sample in the PDX model.
These results demonstrate the effects of different drug combinations on lung-tumors. Scale PDX models are more abundant in tumor heterogeneity. Each PDX model can be considered as a single tumor patient and fully embodies the patient group characteristics. Therefore, therapeutic efficacy studies in preclinical drug development and discovery in more PDX models are meaningful and predictive.