Animal Models & Cell Lines

Disease Mouse Models

Biocytogen leverages comprehensive gene-editing technologies combined with diverse induction-based disease modeling strategies to generate high-quality mouse and rat models across key therapeutic areas, including tumor immunology, autoimmune diseases, metabolic disorders, cardiovascular disease, neurology, and rare diseases.
All models undergo rigorous and systematic validation to ensure stable phenotypes, reproducibility, and reliable performance in research applications.
Supported by a robust portfolio of precision disease models—including target-humanized mouse strains—Biocytogen provides essential tools for global biomedical research and drug development. These models enable target discovery, candidate molecule screening, and preclinical evaluation, accelerating the development of innovative therapies from early research to clinical translation.
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  • Why Choose Biocytogen's Disease Models?
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      Why Choose Biocytogen's Disease Models?
      • Multi-technology approaches for disease model generation
        Biocytogen integrates gene-editing technologies with chemical induction, pharmacological stimulation, and surgical procedures to establish standardized disease models across oncology, autoimmune diseases, metabolic disorders, cardiovascular biology, neurology, and rare diseases.
      • Robust datasets ensuring model reliability and reproducibility
        Each model is supported by comprehensive gene expression analysis, in-depth phenotypic characterization, and validation using positive-control drugs, ensuring high reproducibility, experimental robustness, and strong translational relevance.
      • Diverse modeling strategies tailored to different R&D needs
        For the same disease, Biocytogen offers multiple modeling approaches to simulate distinct disease stages, mechanisms, and pathological features, enabling flexible alignment with varied therapeutic research and preclinical evaluation scenarios.
      • Integrated models to accelerate biologics development
        Biocytogen's disease models can be combined with target-humanized mouse strains to support antibody discovery, biosimilar evaluation, functional validation, and safety assessment, significantly enhancing the efficiency of biologics development pipelines.
      Featured Products
      Product List
        Product Name Product No. Background Actions
        B-A2ar KO mice(C) 112300 BALB/cCrSlcNifdc
        B-Abca4 KO mice 113760 C57BL/6JNifdc
        B-Abca7*V1613M mice 114002 C57BL/6JNifdc
        B-Abcb4 KO mice(C) 112978 BALB/cCrSlcNifdc
        B-Adamts13 KO mice 113720 C57BL/6JNifdc
        B-Adipor1 KO mice 111259 C57BL/6N
        B-Apoa4 KO rats 210505 SD
        B-Apoe KO mice 110168 C57BL/6
        B-Apoe KO rats 210508 SD
        B-App NL-F mice 112976 C57BL/6JNifdc
        B-App NL-F/Psen1*E120K*M146L mice 113247 C57BL/6JNifdc
        B-App NL-F/Psen1*P117L mice 113345 C57BL/6JNifdc
        B-App NL-G-F mice 113062 C57BL/6JNifdc
        B-BM12 mice 113546 C57BL/6JNifdc
        B-Cep290 KO mice 113755 C57BL/6JNifdc
        B-Col4a5*R471X mice 114173 C57BL/6JNifdc
        B-Csf1r KO mice(CBA) 113819 CBA/CaJ
        B-DIO mice 112938 C57BL/6JNifdc
        B-Dmd KO(del45-50) mice 113915 C57BL/6JNifdc
        B-Dmd KO(del52) mice 114076 C57BL/6JNifdc
        B-F11r KO mice 112452 C57BL/6N
        B-F8 KO mice 110169 C57BL/6N
        B-F9 KO mice 110170 C57BL/6
        B-F9 KO/hFcRn mice 114753 C57BL/6
        B-Flt3-ITD mice 113313 C57BL/6JNifdc
        B-Fmr1 KO mice 112852 C57BL/6N
        B-Glut1 KO mice 114552 C57BL/6JNifdc
        B-Grn KO mice 112567 C57BL/6N
        B-H11-hINV-(HPV16 E6/E7/E5)x2 mice(FVB) 113053 FVB
        B-hAPOE3*R136S mice 114313 C57BL/6JNifdc
        B-hAPOE3/hTFR1 mice 114082 C57BL/6
        B-hAPOE4 mice 112564 C57BL/6JNifdc
        B-hAPOL1-G1 mice 113069 C57BL/6
        B-Hbb-bt KO, Hbb-bs KO mice 113046 C57BL/6N
        B-hCD98HC/hTAU*P301S mice 113206 C57BL/6
        B-hCX3CR1 mice 110101 C57BL/6
        B-hDMD(exon44-46, del45) mice 114088 C57BL/6JNifdc
        B-hDMD(exon44-46, del45)/hTFR1 mice 114214 C57BL/6
        B-hDMD(exon51-53, del52) mice 114172 C57BL/6JNifdc
        B-hDMPK mice 113278 C57BL/6
        B-hDMPK*(CTG)58 mice 114046 C57BL/6
        B-hFGFR3*G380R mice 113287 C57BL/6JNifdc
        B-hFIX/F8 KO mice 113822 C57BL/6
        B-hGAA*c.-32-13T>G mice 114557 C57BL/6
        B-hHSD17B1-luc mice 113541 C57BL/6N
        B-hIGHA1/hCD89 mice 112799 C57BL/6N
        B-hLEPR, Lep KO mice 114626 C57BL/6
        B-hLMNA*G608G mice 113262 C57BL/6
        B-hLPA mice plus 112845 C57BL/6
        B-hLRRK2*G2019S mice 113065 C57BL/6
        B-hMRGPRX2 mice 113653 C57BL/6JNifdc
        B-hMRGPRX4 mice 113571 C57BL/6JNifdc
        B-hPAH*R408W mice 113493 C57BL/6JNifdc
        B-hRHO*P23H mice 113150 C57BL/6JNifdc
        B-hSERPINA1*E342K mice 113041 C57BL/6JNifdc
        B-hSIRPA/hCD47,Apoe KO mice 113182 C57BL/6
        B-hSNCA*A53T mice plus 114090 C57BL/6JNifdc
        B-hSNCA*A53T plus/hIGF1R plus mice 114221 C57BL/6JNifdc
        B-hSORT1 plus, Grn KO mice 113991 C57BL/6N
        B-hTFR1, Dmd KO(del45-50) mice 113967 C57BL/6
        B-hTFR1, Grn KO mice 114004 C57BL/6
        B-hTFR1, Ids KO mice 113102 C57BL/6
        B-hTTR*V30M mice plus 114193 C57BL/6JNifdc
        B-hXDH plus, Uox KO mice 113074 C57BL/6
        B-Igh-J KO mice 111116 C57BL/6N
        B-Igh-J KO mice(C) 111127 BALB/cCrSlcNifdc
        B-Il10 KO mice(C) 112269 BALB/cCrSlcNifdc
        B-Ins2*C96Y mice 112023 C57BL/6N
        B-Irs2 KO mice 112022 C57BL/6N
        B-Klotho KO mice 113377 C57BL/6JNifdc
        B-KP flox mice 113964 C57BL/6N
        B-KPC mice 113579 C57BL/6N
        B-Kras-LSL-G12D mice 114263 C57BL/6N
        B-Ldlr KO mice 113270 C57BL/6JNifdc
        B-Ldlr KO rats 210506 SD
        B-Mc4r KO mice 112986 C57BL/6JNifdc
        B-Mecp2 KO mice 112853 C57BL/6N
        B-Mlkl KO mice 113753 C57BL/6N
        B-MUP-uPA mice 112036 C57BL/6
        B-Mybpc3 KO mice 114363 C57BL/6JNifdc
        B-NDG Fah KO mice 112959 B-NDG
        B-Nlrp3*A350V flox mice 113935 C57BL/6JNifdc
        B-Npc1 KO mice(C) 114550 BALB/cCrSlcNifdc
        B-ob/ob mice 110172 C57BL/6N
        B-Otoferlin KO mice 113547 C57BL/6JNifdc
        B-OX1R KO mice 113613 C57BL/6JNifdc
        B-OX1R KO, OX2R KO mice 113615 C57BL/6JNifdc
        B-OX2R KO mice 113614 C57BL/6JNifdc
        B-p53 KO mice 110167 C57BL/6
        B-p53 KO mice(C) 112011 BALB/cCrSlcNifdc
        B-p53 KO mice(C3H) 112007 C3H
        B-p53 KO mice(DBA2) 112012 DBA/2
        B-p53 KO mice(FVB) 112008 FVB
        B-p53 KO mice(ICR) 112010 ICR
        B-p53 KO rats 210507 SD
        B-Pah KO mice 113306 C57BL/6N
        B-Pde6b KO mice 113759 C57BL/6JNifdc
        B-Pkd1*R3277C mice 114750 C57BL/6JNifdc
        B-PrP-hAPP-hPS1 rats 210510 SD
        B-Psen1*E120K*M146L mice 112977 C57BL/6JNifdc
        B-Psen1*P117L mice 113061 C57BL/6JNifdc
        B-Rpe65 KO mice 113758 C57BL/6JNifdc
        B-Rs1 KO mice 113761 C57BL/6JNifdc
        B-Scn1a KO mice(129S2) 114141 129S2/SvPasCrl
        B-Scn1a KO mice(B6J129S2F1) 114142 (C57BL/6JNifdc X 129S2/SvPasCrl)F1
        B-Sorl1*A528T mice 113725 C57BL/6JNifdc
        B-Tg(hPMP22) mice 113146 C57BL/6JNifdc
        B-Tg(hSOD1*G93A) mice 113197 C57BL/6JNifdc
        B-Tg(hSOD1*G93A)/hTFR1 mice 115302 C57BL/6
        B-Tg(hVEGFA) mice 113126 C57BL/6JNifdc
        B-Tg(Thy1-hTARDBP*A315T) mice 113323 C57BL/6JNifdc
        B-Thy1-hSNCA*A53T mice 114200 C57BL/6JNifdc
        B-Tnf△ARE mice 114474 C57BL/6JNifdc
        B-Trp53 mKI(p.Arg172His) mice 110875 C57BL/6N
        B-Tspan12 KO mice 113972 C57BL/6JNifdc
        B-Uox KO mice plus 113135 C57BL/6JNifdc
        B-vk*MYC mice 112303 C57BL/6N
        B-Zmpste24 KO mice 113378 C57BL/6JNifdc